Although the anabolic ratio of this product is very high as compared to its androgenic actions, not many people report huge weight gains off of Stanozolol. Also, interestingly, it has a relatively weak AR binding ability (7), which is quite unusual for a "cutting" steroid. Many of the effects of this drug, as relates to building muscle, are probably from its very high protein synthesizing ability (6) (8). In addition, since this compound is derived from DHT, it tends to promote a very nice, "quality" look to the user´s muscles, with little or no water retention. Winstrol does not aromatize at any rate and has even been speculated to have anti-progestenic properties (in at least some cases, where it may "block" that receptor) (9). If one were to run ancillary compounds with Stanozolol, perhaps Tamoxifen would be appropriate for it´s beneficial effects on blood lipids, but an anti-estrogen (in it´s classic sense) would be unwarranted; proper post cycle therapy is still needed, though.
As a C17-aa anabolic steroid, Winstrol is hepatotoxic and will present stress to the liver. A common misconception many make is assuming only the oral version of this steroid is hepatotoxic. Winstrol can be found as an oral tablet or as an injectable solution but both forms are C17-aa and both stressful to the liver. In fact, injectable Winstrol is one of the only C17-aa injectable steroids. Many also inaccurately assume this is one of the most hepatotoxic anabolic steroids on the market; again this is false. Stanozolol will carry a greater hepatotoxicity than steroids like Anavar (Oxandrolone) but on a per milligram basis less hepatotoxic than steroids like Dianabol (Methandrostenolone).
The Oxandrolone hormone does not carry any estrogenic related side effects. It does not aromatize and cannot lead to gynecomastia or water retention due to increases in estrogen levels. It further carries no progestin related activity, which again supports no estrogenic related side effects. Due to water retention being impossible with this steroid, this will decrease the risk of high blood pressure. Excess water retention can promote high blood pressure. Some steroids that do not aromatize can lead to high blood pressure, such as Trenbolone , but Anavar is rarely associated with this trait.