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Nebulisers are machines that turn the liquid form of your short-acting bronchodilator medicines into a fine mist, like an aerosol. You breathe this in with a face mask or a mouthpiece. Nebulisers are no more effective than normal inhalers. However, they are extremely useful in people who are very tired (fatigued) with their breathing, or in people who are very breathless. Nebulisers are used mainly in hospital for severe attacks of asthma when large doses of inhaled medicines are needed. They are used less commonly than in the past, as modern spacer devices are usually just as good as nebulisers for giving large doses of inhaled medicines. You do not need any co-ordination to use a nebuliser - you just breathe in and out, and you will breathe in the medicine.
There are no head to head studies comparing Fasenra, Nucala and Cinqair, and likely there will never be. It would be up to the physician and patient to discuss the pros and cons of each medication to determine which treatment course is best. The price tag for these medications are somewhere between $2000-3000/month before insurance. Insurance companies have strict criteria before approving these medications. What kind of insurance coverage a patient has also may also determine which of these medications a patient with severe eosinophilic asthma needs to try first. AstraZeneca will most likely have patient support programs to help with copays for those whose insurances give only partial coverage. Other medications that AstraZeneca uses for milder or more moderate cases of asthma include, Accolate (zafirlukast), Pulmicort (budesonide) and Symbicort (budesonide/formoterol).