Haha, I’m happy I inspired you to add the avene cleanser to this article! 😉 It’s really gentle, and my face actually feels more moisturised after cleansing. I use it once a day, at night. I apply it very gently, and then rinse it off using cool water for only a couple of seconds. The instructions say you don’t have to rinse it off, and instead wipe it off with a cotton pad… but personally I prefer rinsing it off. Athough I highly suggest anyone try this cleanser ESPECIALLY when focusing on fixing their dehydrated skin, I’m not too sure how effective it’d be at removing sunscreen. I personally don’t use sunscreen, so I couldn’t tell you. Maybe if you oil cleanse it’d be fine?
Myxobacterial CYP260B1 from Sorangium cellulosum was heterologously expressed in Escherichia coli and purified. The in vitro conversion of a small focused substrate library comprised of Delta 4 C21-steroids and steroidal drugs using surrogate bovine redox partners shows that CYP260B1 is a novel steroid hydroxylase. CYP260B1 performs the regio- and stereoselective hydroxylation of the glucocorticoid cortodoxone (RSS) to produce 6 beta-OH-RSS. The substrate-free crystal structure of CYP260B1 (PDB 5HIW) was resolved. Docking of the tested ligands into the crystal structure suggested that the C17 hydroxy moiety and the presence of either a keto or a hydroxy group at C11 determine the selectivity of hydroxylation.