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Fauchard was the pioneer of dental prosthesis , and he discovered many methods to replace lost teeth. He suggested that substitutes could be made from carved blocks of ivory or bone . He also introduced dental braces , although they were initially made of gold, he discovered that the teeth position could be corrected as the teeth would follow the pattern of the wires. Waxed linen or silk threads were usually employed to fasten the braces. His contributions to the world of dental science consist primarily of his 1728 publication Le chirurgien dentiste or The Surgeon Dentist. The French text included "basic oral anatomy and function, dental construction, and various operative and restorative techniques, and effectively separated dentistry from the wider category of surgery". [46] [47]

Filoviruses cause disease with high case fatality rates and are considered biological threat agents. Licensed post-exposure therapies that can be administered by the oral route are desired for safe and rapid distribution and uptake in the event of exposure or outbreaks. Favipiravir or T-705 has broad antiviral activity and has already undergone phase II and is undergoing phase III clinical trials for influenza. Here we report the first use of T-705 against Ebola virus. T-705 gave 100% protection against aerosol Ebola virus E718 infection; protection was shown in immune-deficient mice after 14 days of twice-daily dosing. T-705 was also shown to inhibit Ebola virus infection in cell culture. T-705 is likely to be licensed for use against influenza in the near future and could also be used with a new indication for filovirus infection.

Low levels of serotonin , a neurotransmitter in the brain, have been linked to depression . High levels of estrogen, as in first-generation COCPs, and progestin, as in some progestin-only contraceptives, have been shown to lower the brain serotonin levels by increasing the concentration of a brain enzyme that reduces serotonin. This observation, along with some small research studies [66] have inspired speculation that the pill causes depression. In 2016, a large Danish study of one million women showed that use of COCPs, especially among adolescents, was associated with a statistically significantly increased risk of subsequent depression, although the sizes of the effects are small (for example, % of the women who took any form of oral birth control were prescribed anti-depressants for the first time, compared to % of women in the control group). [67]

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Why mention all this? First, this history has created a mystique, whether warranted or not. And second, it has provided us with a great deal of toxicological information. Last, one should be sure that if choosing the drug, the decision is not simply from the mystique. Being the old East German doping drug of choice should be irrelevant to whether an athlete or bodybuilder should choose it today. Instead it should be considered in terms of its positive and negative effects. Among available anabolic steroids, OT offers nothing outstanding here, though it’s certainly usable.

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