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Quercetin appears to be an inhibitor of the Heat Shock Response, a response to heat exposure that results in activation of heat-shock and heat-response proteins [54] [55] that can have wide-reaching effects such increasing intestinal permeability. [56] Specifically, Quercetin has shown inhibition at the level of phosporylation and trimerization in the cytosol [57] [58] [59] and downstream effects on promoter binding [60] and results of genetic signalling (mRNA expression and protein accumulation). [55] Through these effects, it may mitigate the anti-inflammatory effects of Heat-Shock Protein 70 (HSP70). [61] In humans, 30mg/kg quercetin a day (averaged to 2,000mg Quercetin daily) taken with exercise was shown to increase urinary lactulose on day 1, and increase both lactulose and serum endotoxin on day 7 after heat acclimatization should have occurred. [57] These results suggest impairment of intestinal permability acutely, and prevention of beneficial adaptations to heat over continual heat exposure associated with 2g Quercetin supplementation. [57]

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