Stomadynia (burning mouth syndrome) is characterized by a burning pain in the oral mucosa that cannot be attibuated to any visible organic cause. The first study illustrated how the use of multivariate analyses can help to classify chronic pain including stomatodynia. When signs and symptoms describing topographics features were not included in the list of variables, the idiopathique orofacial pain patients tended to cluster in a single group. Inside this large cluster, only stomatodynia emerged as a distinct homogenous subgroup. Stomatodynia had no recognised sucessuf treatements. The second work presented used a multicentric, randomised, double-blind parallel group design to investigate the effects of the topical application of clonazepam in patients with stomatodynia. The results demonstrated that sucking clonazepam tablet improved the pain symptoms of stomatodynia in two-thirds of the included subjects. Stomatodynia propably depends on several neuropathic mechanisms and tropical administration of clonazepam may be useful only when the dominating mechanisms are peripheral. The aim of the third study exposed in this work was to identify whether a peripheral neuropathic component was part of the mechanism leading to the effects of lingual nerve block in patients, it had contrasted actions depending on the individuals ( increase, decrease or no effect on spontaneous burning). The lingual block effects suggested that both peripheral and central neuropathic mechanisms may be at work in stomatodynia and that in a given individual, one of these two mechanisms may be dominating. The process leading to these pathological changes in the peripheral or central nervous system remains to be elucitaded. Thus, the last part presented in this work led to the hypothesis that the neuropathic nature of stomatodynia could be due to significant changes involving gonadal and adrenal steroids as well as some similar molecules locally synthesized and called neuroactive steroids. Read more... Rating: (not yet rated) 0 with reviews - Be the first.