Some bodybuilders and athletes use trenbolone for its muscle-building and otherwise performance-enhancing effects. [ citation needed ] Such use is illegal in the United States and many other countries. The DEA classifies trenbolone as a Schedule III controlled substance under the Controlled Substances Act .  Trenbolone is classified as a Schedule 4 drug in Canada  and a class C drug with no penalty for personal use or possession in the United Kingdom .  Use or possession of steroids without a prescription is a crime in Australia .  The infamous "duchess" cocktail administered to Russian athletes at the Sochi Winter Olympics consisted of oxandrolone , metenolone , and trenbolone. 
In androgen receptor studies, oral Trenbolone enanthate and acetate shows nearly no attraction or binding to the sex hormone binding proteins. This makes it an extremely attractive choice as Oral Tren demonstrates equal affinity for and binding to all tissues regardless of the quantity and presence of these proteins. This is the reason Oral Tren is a good choice in terms of supposed binding capacity. However, there is a risk of liver toxicity in certain cases so Milk Thistle should be used with it. Furthermore, those taking Oral Tren are recommended to drink 7 to 9 glasses of water a day while using Trenbolone.