Testosterone replacement therapy has been used since the 1940s. Injections, usually given every few weeks, are one of the oldest ways to increase testosterone. Gels are used widely in the . They are applied daily to the shoulder, abdomen, or upper arm. The general goal of treatment is to raise the blood testosterone level only into the mid-normal range -- about 400-700 ng/dL. Other methods include patches, oral adhesive tablets and TESTOPEL (testosterone pellets), which is a pellet that is injected subcutaneously and can last 3-6 months.
A 2010 study revealed that a decrease in T explained much of the loss in phase III and IV sleep, or "deep sleep" that is characteristic of aging males.  At age 50, men spend 5-7 percent of their sleep time in Phase III and IV and by age 60 it is nearly zero or nonexistent. Young men, on the other hand, spend 10-20 percent of thier total sleep time in these stages due to neuronal integrity and abundant testosterone levels..
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